Detective Chief Superintendent Mick Duthie warned police would strive to bring more rapists to justice by targeting male behaviour, including shutting troublesome properties down.
In an interview with the Guardian newspaper, he said: "We are looking at areas that generate high levels of sexual offences, identifying nightclubs or pubs where this might happen, and which we can link back to rapes and use the licensing laws against these premises."
He added they would also be advising potential victims about leaving themselves vulnerable, as well as using covert policing tactics to take perpetrators off the streets.
The drive, to be implemented by the Met's sex crime unit Sapphire, is aimed at combating a significant decrease in the number of rapes reported to police in London.
Detective Chief Superintendent Duthie told the newspaper: ""If you were in Lewisham High Street at night and someone had a glass or bottle stuck in their neck, we would use the licensing legislation to close that place down.
"But until now we haven't done that for sexual offences."
He added the reasons for a reduction in rape complaints was "a concern", saying it was unclear whether it was because there were less sex attacks happening, better intervention at an earlier stage or less reports.
"If they are not reporting, why are they not reporting?" he said.
"Is it because victims are losing confidence because there is a perception they won't get justice, and people won't get charged? We are doing significant work at the moment with our partners looking into all of that."
The new tactics will include advising women about how they can be less vulnerable to attack.
"We have to make sure we are not targeting the victims but the suspects," he said.
"But we do need to educate people that if they go out and get hammered they are vulnerable - vulnerable to being assaulted - vulnerable to falling over and vulnerable to being raped.
"80 per cent of our victims have one form of vulnerability or another, a permanent or temporary vulnerability through drink, drugs, mental health, age. So there are things that we can do to prevent the offence happening in the first place."
